Wales look to make it two from two in their World Cup qualifying group when they take on North Macedonia on Tuesday night (1945 GMT).
The Thomas Tuchel era begins as England kick-off their World Cup qualifying campaign with a home game against Albania on Friday night (1945 GMT).
Liverpool look to continue their dream season as they host PSG in the second leg of their Champions League round of 16 clash on Tuesday night (2000 GMT).
West Ham host Wembley-bound Newcastle in the Premier League on Monday night, with the Hammers looking to seal a first league double over the Toon in six years (2000 GMT).
Arsenal look to draw first blood in their Champions League round of 16 tie when they travel to Eindhoven to take on PSV on Tuesday night (2000 GMT).
Nottingham Forest look to halt their three game winless run when they host Premier League strugglers Ipswich at the City Ground in the FA Cup on Monday night (1930 GMT).
Chelsea have been stuttering in the league recently, but Enzo Marseca's men have an excellent opportunity to get back to winning ways when they host Southampton on Tuesday night (2015 GMT).
The Championship's top two meet on Monday night as Leeds and Sheffield United look to land a significant blow in the race for the Premier League (2000 GMT).
Celtic face the daunting task of a trip to the Allianz Arena as they try to overturn a one-goal deficit against German giants Bayern Munich on Tuesday night (2000 GMT).
Leeds look to reclaim top spot in the Championship when they take on promotion rivals Sunderland at Elland Road on Monday night (2000 GMT).
