His quest to add to that solitary Major has seen him come painfully close but fall narrowly short on several occasions. He has finished as runner-up in all four Majors, losing playoffs at the 2012 Masters and the 2015 British Open, while narrowly missing out on three separate occasions in 2021.
Oosthuizen credits the round of 57 he shot at the Mossel Bay Golf Course in 2002 with giving him the self-belief to pursue a career in the sport.
Winning the 2013 Volvo Golf Champions propelled Oosthuizen to a career-high fourth place in the Official World Golf Rankings.
Oosthuizen doesn't have the power game of some of the latest generation of golfers but his smooth, rythmical swing is one of the most admired in the game.
Amateur career
Turning pro
The European Tour is calling
A tie for 14th at the Andalucia Open de Espana was his best showing in his first European Tour campaign as a full member.
In 2007, he notched three victories on the Sunshine Tour, narrowly missing out on claiming the Order of Merit. He made a single appearance on the PGA Tour, finishing tied 50th at the WGC-CA Championship.
Oosthuizen's early attempts at Major glory did not go according to plan as he missed the cut at The Masters, the British Open and the PGA Championship in 2009. But he did come close to a first victory on the European Tour in January when he finished runner-up at the Abu Dhabi Golf Championship and the Qatar Masters on successive weekends.
Taste of Major success but also near misses
Ranked outside of the world's top 50 coming into the 2010 Open Championship at St Andrews, Oosthuizen stunned the world of golf with a dominant display. In the second round, he seized the lead from Rory McIlroy and went on a charge that would see him win the Claret Jug by seven strokes.
Oosthuizen pushed for another Major but second would be the best he could manage. He finished as runner-up at the 2012 Masters and in 2015 came second at both the US Open and Open Championship. In 2017, he fell just short yet again, this time at the PGA Championship.
On his way to finishing as a bridesmaid at the 2012 Masters, he made history with an incredible albatross at the par-5 second hole.
His playoff defeat to Bubba Watson at The Masters and subsequent heartbreaks in the other American Majors means, amazingly, he's still yet to win a tournament on US soil.
His last professional win came at the 2018 South African Open but he's had a spate of near misses since - mostly in Majors.
In 2021, he was the halfway leader at the PGA before finishing tied second and then had to settle for another runner-up finish after being pipped by Jon Rahm in the US Open after the Spaniard birdied the final two holes.
Louis Oosthuizen's personal life
Louis Oosthuizen's net worth
It is not uncommon for a Major winner to splash out on a new luxury vehicle to celebrate, but Oosthuizen bought himself a John Deere tractor with his British Open prize money.